Champions Barcelona scored an easy 3-0 home win over high-flying Osasuna in the Primera Liga.
Barcelona's fourth defeat of the season left them seventh in the standings on 14 points after 10 games, 12 points behind leaders Atletico.
Eleven-times champion Rafael Nadal booked his place in the semi-finals of the Barcelona Open semi-finals by beating German Jan-Lennard Struff 7-5, 7-5 in a hard-fought match on Friday.
Real have three days to recover from the humbling defeat before Saturday's crunch local derby against Atletico Madrid
Atletico Madrid took full advantage of Barcelona's defeat at Real Sociedad and closed to within eight points of the La Liga leaders when Adrian and Koke struck in a 2-0 win at home to Levante on Sunday.
Barcelona snatched a late 2-1 win at Getafe with Paulinho's strike sending them seven points clear of arch-rivals Real Madrid at the top of La Liga.
Cristian Tello hit a hat-trick as Barcelona came from behind to win 4-1 in their King's Cup quarter-final first leg at Levante on Wednesday and Lionel Messi celebrated his 400th appearance for the Catalan side.
All the action from La Liga and Serie A matches played on Monday
Twenty-three-times Cup winners Athletic Bilbao were dumped out in sensational circumstances by tiny island side SD Formentera, who sneaked a 1-0 win at San Mames with a header by Alvaro Muniz deep in stoppage-time to reach the last 16 for the first time with a 2-1 aggregate victory.
English Premier League leaders Manchester City and Chelsea slugged out a magnificent 4-4 draw at Stamford Bridge.
Portugal's Bernardo Silva and Cristiano Ronaldo scored first-half goals in a comfortable 3-1 win away to Poland in the Nations League on Saturday as the Group A1 leaders continued their perfect start to the competition with three wins.
Barcelona's hopes of staging another sensational Champions League comeback fell flat against a hardened Juventus side who held the Catalans to a 0-0 draw at the Nou Camp on Wednesday to reach the semi-finals 3-0 on aggregate.
Diego Costa continued his rich vein of form as he helped leaders Chelsea to a 3-0 win over Aston Villa while Louis van Gaal enjoyed only his second Premier League win as Manchester United manager following a 2-1 victory against West Ham.
Real Madrid thrashed Deportivo La Coruna 6-2 to stay level with Barcelona at the top of La Liga on Wednesday after the Catalans crushed Osasuna 7-1, condemning the minnows to relegation.
Cristiano Ronaldo made an immediate impact on his return from a COVID-19 infection on Sunday, scoring three minutes after coming on as a substitute before converting a penalty to lead Juventus to a 4-1 Serie A win at Spezia.
IMAGES from the UEFA Champions League matches played on Wednesday
World number two Rafael Nadal dropped a set at the Barcelona Open for the first time in four years before advancing to the last 16, beating Argentine Leonardo Mayer 6-7(7), 6-4, 6-2 on Wednesday.
Barcelona's fading hopes of capturing a fourth consecutive La Liga crown suffered a major setback when they lost 3-2 at Osasuna on Saturday to leave Real Madrid seven points clear at the top with a game in hand.
A summary of Wednesday's matches in the UEFA Champions League.
Barcelona moved ever closer towards a successful defence of their La Liga title after nearest challengers Atletico Madrid suffered a shock late collapse at struggling Sporting Gijon to lose 2-1 on Saturday.
IMAGES from the Champions League matches played on Tuesday.
Luis Suarez scored a hat-trick, including an exquisite second goal, as Barcelona strolled into the Club World Cup final with a 3-0 win over Asian champions Guangzhou Evergrande on Thursday.
News of all that's transpired on and off the football field
Subdued atmosphere at the Nou Camp after the deadly attacks in the Catalan capital and the town of Cambrils.
Barcelona's Lionel Messi rescued a 1-1 draw at Villarreal with a sensational late free-kick on Sunday but could not prevent the champions finishing the weekend third in La Liga, five points behind leaders Real Madrid.
Barcelona won the La Liga title with a comfortable 3-0 victory at Granada thanks to a Luis Suarez hat-trick in the season finale on Saturday.
Barcelona forwards Ousmane Dembele and Lionel Messi fired the Catalans to a confidence-boosting 2-0 win at in-form Sevilla on Saturday to keep the pressure on La Liga leaders Atletico Madrid.
Barcelona finally made a statement of intent in what has been a chaotic season as they came from behind to beat La Liga leaders Real Sociedad 2-1 at home on Wednesday.
Twice finalist Ruud overcomes Davidovich Fokina test
'There is not the slightest hint of crime'
Rafael Nadal extended his astonishing winning run on clay to 42 consecutive sets as he reached the semi-finals of the Barcelona Open with a 6-0, 7-5 victory over Slovakia's Martin Klizan on Friday. The defending champion will face David Goffin on Saturday after the Belgian beat Spaniard Roberto Bautista 6-7(3), 6-2, 6-2.
Karim Benzema scored twice after the interval with a penalty and a header from a corner to give Santiago Solari's side a 3-1 lead, after Raphael Varane struck in the 34th minute to cancel out Anuar Tuhami's goal for Valladolid five minutes earlier.
Bayern Munich and Barcelona registered easy wins, while Manchester United came from behind to beat CSKA Moscow 2-1 and Chelsea surrendered the top spot after a 1-1 at home against Atletico Madrid.
Real Madrid were dumped out of the Copa del Rey at the quarter-final stage on Thursday after losing 4-3 at home to Real Sociedad, while record 30-times winners Barcelona were sent crashing out of the Copa del Rey in a 1-0 defeat at Athletic Bilbao.
Neymar scored twice as Barcelona reached the Champions League semi-finals.
A first-half penalty earned Lille a shock 1-0 home victory over holders Real Madrid in the Champions League group phase on Wednesday.
Lionel Messi notched a 20th assist of the season to help a lacklustre Barcelona secure a 1-0 win away to Real Valladolid on Saturday, maintaining the pressure on La Liga leaders Real Madrid. Cristiano Ronaldo converted two penalties, both awarded for handballs and the second in the last minute, as Serie A leader Juventus twice hit back to draw 2-2 with Atalanta to move closer to a ninth successive Serie A title on Saturday.
Substitute Sergio Araujo struck a late equaliser as Las Palmas held Real Madrid to a 2-2 draw and left them with a one-point lead over Barcelona at the top of La Liga on Saturday.
Arsenal will face manager Arsene Wenger's former club Monaco with defending champions Real Madrid pitted against German club Schalke.
